منابع مشابه
PMNCH gains traction and a new leader.
“Where I’m going there’s good energy and real excitement with so many different constituencies working to achieve the same goals”, says Robin Gorna, who takes up her new post on Feb 1 as executive director of the Partnership for Maternal, Newborn & Child Health (PMNCH), hosted in WHO’s headquarters in Geneva, Switzerland. On Jan 31, she will leave her post as executive director of AIDS Strategy...
متن کاملChemical activation of the mechanotransduction channel Piezo1
Piezo ion channels are activated by various types of mechanical stimuli and function as biological pressure sensors in both vertebrates and invertebrates. To date, mechanical stimuli are the only means to activate Piezo ion channels and whether other modes of activation exist is not known. In this study, we screened ~3.25 million compounds using a cell-based fluorescence assay and identified a ...
متن کاملPiezo1
Piezo ion channels have been found to be essential for mechanical responses in cells. These channels were first shown to exist in Neuro2A cells, and the gene was identified by siRNAs that diminished the mechanical response. Piezo channels are approximately 2500 amino acids long, have between 24-32 transmembrane regions, and appear to assemble into tetramers and require no other proteins for act...
متن کاملGating the mechanical channel Piezo1
Piezo1 is a eukaryotic cation-selective mechanosensitive ion channel. To understand channel function in vivo, we first need to analyze and compare the response in the whole cell and the patch. In patches, Piezo1 inactivates and the current is fit well by a 3-state model with a single pressure-dependent rate. However, repeated stimulation led to an irreversible loss of inactivation. Remarkably, ...
متن کاملMicroglia mechanics: immune activation alters traction forces and durotaxis
Microglial cells are key players in the primary immune response of the central nervous system. They are highly active and motile cells that chemically and mechanically interact with their environment. While the impact of chemical signaling on microglia function has been studied in much detail, the current understanding of mechanical signaling is very limited. When cultured on compliant substrat...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2021
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2021.35.s1.00018